Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats.

@article{GilliamDavis2007LongtermAR,
  title={Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats.},
  author={Shea Gilliam-Davis and Valerie S. Payne and Sherry O. Kasper and Ellen N. Tommasi and Michael E. C. Robbins and Debra I. Diz},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 3},
  pages={H1327-33}
}
Fischer-344 (F344) rats exhibit proteinuria and insulin resistance in the absence of hypertension as they age. We determined the effects of long-term (1 yr) treatment with the angiotensin (ANG) II type 1 (AT(1)) receptor blocker L-158,809 on plasma and urinary ANG peptide levels, systolic blood pressure (SBP), and indexes of glucose metabolism in 15-mo-old male F344 rats. Young rats at 3 mo of age (n = 8) were compared with two separate groups of older rats: one control group (n = 7) and one… CONTINUE READING