Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine.

@article{Laconi1998LongtermNL,
  title={Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine.},
  author={Ezio Laconi and Ran Oren and Deep Kishore Mukhopadhyay and E Hurston and Sergio Laconi and Paolo Pani and Mariana D. Dabeva and David A. Shafritz},
  journal={The American journal of pathology},
  year={1998},
  volume={153 1},
  pages={319-29}
}
Genetically marked hepatocytes from dipeptidyl peptidase (DPP) IV+ Fischer 344 rats were transplanted into the liver of DPPIV- mutant Fischer 344 rats after a combined treatment with retrorsine, a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, and two-thirds partial hepatectomy. In female rats, clusters of proliferated DPPIV+ hepatocytes containing 20 to 50 cells/cluster, mostly derived from single transplanted cells, were evident at 2 weeks, increasing in size to hundreds of… CONTINUE READING

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