Long survival and clinical stability in Marburg’s variant multiple sclerosis

  title={Long survival and clinical stability in Marburg’s variant multiple sclerosis},
  author={Marco Turatti and Alberto Gajofatto and Francesca Rossi and Marcella Vedovello and Maria Donata Benedetti},
  journal={Neurological Sciences},
Marburg’s variant multiple sclerosis (MS) is an acute and aggressive atypical form of MS, leading frequently to death in few months. A 32-year-old man with motor and sensory symptoms suggestive of acute myelopathy, rapidly followed by cerebellar dysfunction and consciousness impairment. Clinical, laboratory and radiological evaluations suggested a central nervous system demyelinating disease. The diagnosis was Marburg’s variant MS, usually leading to death in short time. He underwent different… 

A second case of Marburg’s variant of multiple sclerosis with vasculitis and extensive demyelination

A case of a 31-year-old woman with Marburg’s variant of MS who, over a period of eight months, became totally disabled, blind, and quadriplegic, with vocal cord paralysis, requiring a tracheostomy is reported.

Marburg Multiple Sclerosis Variant: Complete Remission with Very Early Administration of Mitoxantrone—A Case Report

The inflammatory explosive case of a 31-year-old woman presenting with rapid neurological degradation of histology proven Marburg’s disease, successfully treated with early administration of Mitoxantrone (MITX), which is the first case describing complete remission after MITX in a biopsy-proven condition.

Marburg's Variant of Multiple Sclerosis with Extensive Brain Lesions: An Autopsy Case Report

Even when marked improvement following IV methylprednisolone is observed, adjunct therapy with a second modality should be considered to improve the chance of survival.

A case of acute fulminant multiple sclerosis treated with alemtuzumab.

Fulminant Demyelinating Diseases

This review highlights the discriminating clinical, radiographic, and pathologic features of Fulminant demyelinating disease, which covers acute disseminated encephalomyelitis and its variant acute hemorrhagic leukoencephalitis, severe relapses of multiple sclerosis, variants of MS, and neuromyelitas optica-spectrum disorders associated with aquaporin autoimmunity.

Recurrent Fulminant Tumefactive Demyelination With Marburg-Like Features and Atypical Presentation: Therapeutic Dilemmas and Review of Literature

A very rare case of recurrent tumefactive demyelinating lesions, with atypical tumor-like characteristics, with initial response to corticosteroids and cyclophosphamide, but subsequent development of drug-resistance and unexpected exacerbation upon rituximab administration is presented.

Atypical Inflammatory Demyelinating Syndromes of the Central Nervous System

  • T. Hardy
  • Psychology, Medicine
    Contemporary Clinical Neuroscience
  • 2019
The difficulties in diagnosing and distinguishing between conditions such as acute disseminated encephalomyelitis, tumefactive demyelination, Balo’s concentric sclerosis, Marburg's multiple sclerosis, and Schilder's diffuse myelinoclastic sclerosis are discussed.

Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders

This article reviews the recent literature on the clinical presentation; radiographic features; prognosis; and management of tumefactive demyelinating lesions in multiple sclerosis, acute demYelinating encephalomyelitis, neuromyELitis optica, and the rare variants of multiple sclerosis including Schilder’s disease, Marburg acutemultiple sclerosis, and Balo's concentric sclerosis.

Tumefactive demyelinating lesions in multiple sclerosis

The aim of this monograph is to provide a history of canine coronavirus infection in the context of treatment-preventable disease and to establish a chronology of events leading to and including coronaviruses.



Treatment of Marburg Variant Multiple Sclerosis with Mitoxantrone

Marburg variant multiple sclerosis (MS) is a severe, sometimes monophasic, form of MS leading to advanced disability or death within a period of weeks to months. No consistently successful treatment

Fulminant monophasic multiple sclerosis, Marburg's type.

The clinical, neuroradiological and necropsy findings are described in a 49 year old woman with long-standing idiopathic pulmonary haemosiderosis and acute monophasic multiple sclerosis (Marburg's type) who died 10 weeks after onset of symptoms.

A Case of Rapid Deterioration: Acute Multiple Sclerosis of the Marburg Type

  • J. JaspersonA. G. Jones
  • Medicine, Psychology
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • 1998
A case presentation of a patient with the Marburg variant of MS raises the neuroscience nurse's understanding of the challenges associated with caring for patients with this unusual form of MS.

An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy

A case of malignant monophasic multiple sclerosis (Marburg's disease type) successfully treated with decompressive hemicraniectomy

A case of acute tumour-like demyelination encephalitis diagnosed as an acute variant of MS in which left decompressive hemicraniectomy (DHC) reversed the fulminant course of disease.

Malignant monophasic multiple sclerosis or “Marburg's disease"

Newimaging showed progressive white matter attenuation, and newpathology was characteristic of multiple sclerosis, leading to death 29 days after onset in a patient with an acute monophasic demyelinating disease.

Acute multiple sclerosis (marburg type) is associated with developmentally immature myelin basic protein

The data are consistent with a genetic factor influencing the charge microheterogeneity of MBP, meaning that the resulting less cationic MBP cannot carry out its normal function of compacting multilayers.

Consensus definitions proposed for pediatric multiple sclerosis and related disorders

CNS inflammatory demyelinating disorders presenting in children and adolescents can be defined and distinguished, however, prospective research is necessary to determine the validity and utility of the proposed diagnostic categories.

Four-year follow-up of a case of acute multiple sclerosis of the Marburg type

We describe the clinical course, treatment and magnetic resonance findings during a four-year follow-up of a patient with acute multiple sclerosis of the Marburg type, treated with steroid and