Long remissions in hairy cell leukemia with purine analogs

@article{Else2005LongRI,
  title={Long remissions in hairy cell leukemia with purine analogs},
  author={Monica Else and Rosa Ruchlemer and Nnenna Osuji and Ilaria Del Giudice and Estella Matutes and Anthony C. Woodman and Andrew C. Wotherspoon and John G Swansbury and Claire Dearden and Daniel Catovsky},
  journal={Cancer},
  year={2005},
  volume={104}
}
Both pentostatin and cladribine have efficacy in hairy cell leukemia (HCL), but it is not known which agent achieves better results. 
Hairy cell leukemia
Historically, the first treatment choices for hairy cell leukemia (HCL) were splenectomy and alpha‐interferon. Recently, purine analogues (pentostatin and cladribine) changed radically the treatmentExpand
Hairy cell leukemia
Hairy cell leukemia is a rare B-cell neoplasm. When treated with either pentostatin or cladribine, complete and durable remissions can be secured and life expectancy for most patients is normal. AExpand
Sustained long‐term remissions with weekly interferon maintenance therapy in hairy cell leukemia
Aim:  This study evaluates the efficacy of weekly α‐interferon (IFN) maintenance therapy in hairy cell leukaemia (HCL), a disease that remains incurable.
Time to Cure Hairy Cell Leukemia
  • I. Levy, T. Tadmor
  • Medicine
  • Turkish journal of haematology : official journal of Turkish Society of Haematology
  • 2017
TLDR
First-line therapy for patients with HCL and even second- line therapy have not been substantially changed in the last 30 years. Expand
The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia
The purine analogs pentostatin and cladribine have revolutionized the treatment of hairy cell leukemia (HCL) with overall responses in greater than 85% of patients and a median progression‐freeExpand
Hairy cell leukemia, blastic type: description of spleen morphology and immunophenotype of a distinctive case
TLDR
Hairy cell leukemia (HCL) was first described in 1958 by Bouroncle et al., who named it leukemic reticuloendotheliosis, and introduced the term ‘hairy cell’ in 1966. Expand
Hairy cell leukemia
TLDR
The purpose of this review will be to establish the current status of HCL with respect to its pathophysiology, diagnosis, management, and future directions. Expand
Historical aspects and milestones in the development of effective treatment for hairy cell leukemia
TLDR
Immunoconjugate Therapy with BLZZ (anti-CDZZ antibody linked to truncated to Pseudomonas exotoxin) represents the newest milestone in the development of effective treatment for hairy cell leukemia. Expand
Immunotoxins in the treatment of refractory hairy cell leukemia.
TLDR
Both immunotoxins, termed LMB-2 and BL22, respectively, have been tested in patients who have HCL after failure of purine analogs and other therapies; major responses have been achieved in most patients. Expand
2-CdA in the treatment of hairy cell leukemia: a review of long-term follow-up
TLDR
Repeat administration of 2-CdA is very effective in achieving a second CR and new agents such rituximab and BL22 were shown to be effective in the treatment of relapsed and refractory disease. Expand
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References

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Phase II study of cladribine (2CDA) followed by rituximab for eradication of minimal residual disease (MRD) in hairy cell leukemia (HCL)
6620 Background: HCL is an indolent lymphoproliferative malignancy characterized by infiltration of the bone marrow, liver, and spleen by neoplastic B-cells with cytoplasmic hair-like projections. ...
Long term outcome of patients with hairy cell leukemia treated with pentostatin
TLDR
Investigation of response and long term follow-up in HCL patients treated with pentostatin found pentosteratin to produce higher complete remission rates than IFN. Expand
Deoxycoformycin in the treatment of patients with hairy cell leukemia
Deoxycoformycin (DCF) has been reported to produce high response rates in patients with hairy cell leukemia (HCL), but to the authors' knowledge data regarding experience with such therapy in a largeExpand
Comparison of pentostatin and alpha interferon in splenectomized patients with active hairy cell leukemia: an intergroup study. Cancer and Leukemia Group B and South-West Oncology Group.
  • K. Rai
  • Medicine
  • Leukemia & lymphoma
  • 1994
TLDR
It is shown that as compared to alpha interferon (aIF), pentostatin resulted in a higher incidence of response, but the difference was not statistically significantly, which confirms previous observations that both these agents have important place in therapy of hairy cell leukemia. Expand
Cladribine in the treatment of hairy-cell leukaemia.
TLDR
The history, rationale, chemical structure and mechanism of action of cladribine, a purine nucleoside analogue, and the indications for therapy and guidelines for clinical usage are reviewed. Expand
Long‐term follow‐up of patients with hairy cell leukaemia treated with pentostatin: lymphocyte subpopulations and residual bone marrow infiltration
Summary. Peripheral blood lymphocyte (PBL) subsets and bone marrow biopsies were analysed in six patients with hairy cell leukaemia (HCL) treated with 2′‐deoxycoformycin (pentostatin, DCF) accordingExpand
Pentostatin induces durable remissions in hairy cell leukemia.
TLDR
dCF therapy produces durable long-term, disease-free survival in patients with hairy cell leukemia and reaches maximal response after reaching maximal response. Expand
Extended follow-up of patients with hairy cell leukemia after treatment with cladribine.
TLDR
These results confirm previous observations that single courses of cladribine administered to patients with HCL induce high response rates, the majority of which are CRs. Expand
Rituximab, a chimaeric anti‐CD20 monoclonal antibody, in the treatment of hairy cell leukaemia
TLDR
Rituximab appears promising in the treatment of HCL and warrants further studies. Expand
Long-term outcome with pentostatin treatment in hairy cell leukemia patients. A French retrospective study of 238 patients
TLDR
Pentostatin is a highly effective regimen for hairy cell leukemia that produces durable complete responses and Subsequent malignancies do not appear to be increased with pentostatin treatment. Expand
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