Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades

@article{Markevich2006LongrangeSB,
  title={Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades},
  author={Nick I. Markevich and Mikhail A Tsyganov and Jan B. Hoek and Boris N. Kholodenko},
  journal={Molecular Systems Biology},
  year={2006},
  volume={2},
  pages={61 - 61}
}
A hallmark of protein kinase/phosphatase cascades, including mitogen-activated protein kinase (MAPK) pathways, is the spatial separation of their components within cells. The top-level kinase, MAP3K, is phosphorylated at the cell membrane, and cytoplasmic kinases at sequential downstream levels (MAP2K and MAPK) spread the signal to distant targets. Given measured protein diffusivity and phosphatase activities, signal propagation by diffusion would result in a steep decline of MAP2K activity and… CONTINUE READING

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