Long-range repression in the Drosophila embryo.

  title={Long-range repression in the Drosophila embryo.},
  author={Haini Cai and David N. Arnosti and Michael Levine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 18},
Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types… CONTINUE READING