Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways

@article{Dallosso2012LongrangeES,
  title={Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways},
  author={Anthony R. Dallosso and Bodil \Oster and Alexander Greenhough and Kasper Thorsen and Thomas J. Curry and Carolyn Amann Paul Pearson Mike Owen and Anne L. Hancock and Marianna Szemes and Christos Paraskeva and Martin M. Frank and Claus Lindbjerg Andersen and Karim Malik},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={4409-4419}
}
Loss of tumour suppressor gene function can occur as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigenetic silencing (LRES), and genome-wide analyses have revealed that LRES is present in many cancer types. Here we utilize Illumina Beadchip methylation array analysis to identify LRES across 800 kb of chromosome 5q31 in colorectal adenomas and carcinomas (n=34) relative to normal colonic epithelial DNA (n=6). This region encompasses 53 individual… CONTINUE READING

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