Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells.

@article{Javierre2011LongrangeES,
  title={Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells.},
  author={Biola Maria Javierre and Javier Rodr{\'i}guez-Ubreva and F{\'a}tima Al-Shahrour and Marina Corominas and Osvaldo Gra{\~n}a and Laura Ciudad and Xabier Agirre and David G. Pisano and Alfonso Val{\'e}ncia and Jos{\'e} Rom{\'a}n-G{\'o}mez and Mar{\'i}a Jos{\'e} Calasanz and Felipe Pr{\'o}sper and Manel Esteller and Rogelio Gonz{\'a}lez-Sarmiento and Esteban Ballestar},
  journal={Molecular cancer research : MCR},
  year={2011},
  volume={9 8},
  pages={
          1139-51
        }
}
  • Biola Maria Javierre, Javier Rodríguez-Ubreva, +12 authors Esteban Ballestar
  • Published in
    Molecular cancer research…
    2011
  • Biology, Medicine
  • Transcription factors are common targets of epigenetic inactivation in human cancer. Promoter hypermethylation and subsequent silencing of transcription factors can lead to further deregulation of their targets. In this study, we explored the potential epigenetic deregulation in cancer of Ikaros family genes, which code for essential transcription factors in cell differentiation and exhibit genetic defects in hematologic neoplasias. Unexpectedly, our analysis revealed that Ikaros undergoes very… CONTINUE READING

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