Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

@inproceedings{Lemire2015LongrangeER,
  title={Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci},
  author={Mathieu Lemire and Syed Hassan Ejaz Zaidi and Maria Ban and Bing Ge and Dylan A{\"i}ssi and Marine Germain and Irfahan Kassam and Mike Dai Wang and Brent W. Zanke and France Gagnon and Pierre-Emmanuel Morange and David A Tr{\'e}gou{\"e}t and Philip S Wells and Stephen J Sawcer and Steven J Gallinger and Tomi Pastinen and Thomas J. Hudson},
  booktitle={Nature communications},
  year={2015}
}
The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) (P<3.2 × 10(-13); FDR<5%). These trans-meQTLs include 1,657 SNP-CpG pairs from different… CONTINUE READING
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