Long-range enhancer–promoter contacts in gene expression control

  title={Long-range enhancer–promoter contacts in gene expression control},
  author={Stefan Schoenfelder and Peter Fraser},
  journal={Nature Reviews Genetics},
Spatiotemporal gene expression programmes are orchestrated by transcriptional enhancers, which are key regulatory DNA elements that engage in physical contacts with their target-gene promoters, often bridging considerable genomic distances. Recent progress in genomics, genome editing and microscopy methodologies have enabled the genome-wide mapping of enhancer–promoter contacts and their functional dissection. In this Review, we discuss novel concepts on how enhancer–promoter interactions are… 

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