Long-range effects of retroviral insertion on c-myb: overexpression may be obscured by silencing during tumor growth in vitro.

@article{Hanlon2003LongrangeEO,
  title={Long-range effects of retroviral insertion on c-myb: overexpression may be obscured by silencing during tumor growth in vitro.},
  author={Linda Hanlon and Nighean I Barr and Karen Blyth and Monica L. Stewart and Peter Haviernik and Linda Wolff and Kathleen Weston and Ewan R Cameron and James C Neil},
  journal={Journal of virology},
  year={2003},
  volume={77 2},
  pages={1059-68}
}
The c-myb oncogene is a frequent target for retroviral activation in hemopoietic tumors of avian and mammalian species. While insertions can target the gene directly, numerous clusters of retroviral insertion sites have been identified which map close to c-myb and outside the transcription unit in T-lymphomas (Ahi-1, fit-1, and Mis-2) and monocytic and… CONTINUE READING