Long-range correlations in nucleotide sequences

  title={Long-range correlations in nucleotide sequences},
  author={Chung-Kang Peng and Sergey V. Buldyrev and Ary L. Goldberger and Shlomo Havlin and Francesco Sciortino and Michael Simons and H. Eugene Stanley},
DNA SEQUENCES have been analysed using models, such as an it-step Markov chain, that incorporate the possibility of short-range nucleotide correlations1. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term a 'DNA walk'. We then use the mapping to provide a quantitative measure of the correlation between nucleotides over long distances along the DNA chain. Thus we uncover in the… 

Statistical properties of DNA sequences.

Ising-model description of long-range correlations in DNA sequences.

It is shown that, for distances between 10(3) and 10(6) bp, the correlations show a universal behavior and may be described by the non-mean-field limit of the long-range 1D Ising model, allowing for some testable hypothesis on the nature of the interaction between distant portions of the DNA chain.

A quantitative test of long-range correlations and compositional fluctuations in DNA sequences.

The present study reveals that certain natural DNA sequences (especially those with compact genomes) do have stochastic characteristics which are intrinsically different from artificial sequences.

Long Range Correlations between nucleotide triplets

  • D. VitaleE. KuruogluO. Abul
  • Biology, Chemistry
    Proceedings of the 6th International Symposium on Health Informatics and Bioinformatics
  • 2011
The analysis on nucleotide triplets reveals LRCs for the human Chromosomes 20 and 21, and some triplets that contain only nucleotides Adenine and Thymine are seen to exhibit correlation significantly higher than others.

Statistical and linguistic features of DNA sequences.

We present evidence supporting the idea that the DNA sequence in genes containing noncoding regions is correlated, and that the correlation is remarkably long range--indeed, base pairs thousands of


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