Long-range cis effects of ectopic X-inactivation centres on a mouse autosome

  title={Long-range cis effects of ectopic X-inactivation centres on a mouse autosome},
  author={Jeannie T Lee and Rudolf Jaenisch},
In mammals, the X chromosome is unique in being capable of complete inactivation. Such X inactivation evolved to compensate for gene dosage differences between females with two X chromosomes and males with one1. Transcriptional silencing of a single female X chromosome is controlled in cis by Xist2, whose RNA product coats the inactive X chromosome (Xi)3, and the X inactivation centre (Xic)4. A transgenic study limited the Xic to 450 kilobases including Xist, and demonstrated that it is… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 104 extracted citations

Regulation of X-chromosome inactivation in development in mice and humans.

Microbiology and molecular biology reviews : MMBR • 1998
View 18 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…