Long-range cis effects of ectopic X-inactivation centres on a mouse autosome

@article{Lee1997LongrangeCE,
  title={Long-range cis effects of ectopic X-inactivation centres on a mouse autosome},
  author={Jeannie T Lee and Rudolf Jaenisch},
  journal={Nature},
  year={1997},
  volume={386},
  pages={275-279}
}
In mammals, the X chromosome is unique in being capable of complete inactivation. Such X inactivation evolved to compensate for gene dosage differences between females with two X chromosomes and males with one1. Transcriptional silencing of a single female X chromosome is controlled in cis by Xist2, whose RNA product coats the inactive X chromosome (Xi)3, and the X inactivation centre (Xic)4. A transgenic study limited the Xic to 450 kilobases including Xist, and demonstrated that it is… CONTINUE READING

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