Long range chromatin interactions involved in gene regulation.

  title={Long range chromatin interactions involved in gene regulation.},
  author={Marek Bartkuhn and Rainer Renkawitz},
  journal={Biochimica et biophysica acta},
  volume={1783 11},
Long-distance chromatin interaction has been proposed and demonstrated for enhancer elements separated from the gene by hundreds or thousands of base pairs. This paved the way for the detection of additional enhancer properties, such as the regulation of interaction, and the contacting of genes in trans on other chromosomes. The outspread arrangement of regulatory elements and transcription units requires insulators to prevent the functional interference of enhancer elements with inappropriate… CONTINUE READING