Long-range activation of Sox9 in Odd Sex (Ods) mice.

  title={Long-range activation of Sox9 in Odd Sex (Ods) mice.},
  author={Yangjun Qin and Ling-kun Kong and Christophe Poirier and Cavatina Truong and Paul Overbeek and Colin Edward Bishop},
  journal={Human molecular genetics},
  volume={13 12},
The Odd Sex mouse mutation arose in a transgenic line of mice carrying a tyrosinase minigene driven by the dopachrome tautomerase (Dct) promoter region. The minigene integrated 0.98 Mb upstream of Sox9 and was accompanied by a deletion of 134 kb. This mutation causes female to male sex reversal in XX Ods/+ mice, and a characteristic eye phenotype of microphthalmia with cataracts in all mice carrying the transgene. Ods causes sex reversal in the absence of Sry by upregulating Sox9 expression and… CONTINUE READING


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