Long-range activation of Sox9 in Odd Sex (Ods) mice.

@article{Qin2004LongrangeAO,
  title={Long-range activation of Sox9 in Odd Sex (Ods) mice.},
  author={Yangjun Qin and Ling-kun Kong and Christophe Poirier and Cavatina Truong and Paul Overbeek and Colin Edward Bishop},
  journal={Human molecular genetics},
  year={2004},
  volume={13 12},
  pages={1213-8}
}
The Odd Sex mouse mutation arose in a transgenic line of mice carrying a tyrosinase minigene driven by the dopachrome tautomerase (Dct) promoter region. The minigene integrated 0.98 Mb upstream of Sox9 and was accompanied by a deletion of 134 kb. This mutation causes female to male sex reversal in XX Ods/+ mice, and a characteristic eye phenotype of microphthalmia with cataracts in all mice carrying the transgene. Ods causes sex reversal in the absence of Sry by upregulating Sox9 expression and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…