Long-range Oncogenic Activation of IgH/c-myc Translocations by the IgH 3’ Regulatory Region

Abstract

B-cell malignancies, such as human Burkitt's lymphoma, often contain translocations that link c-myc or other proto-oncogenes to the immunoglobulin heavy chain locus (IgH, encoded by Igh). The nature of elements that activate oncogenes within such translocations has been a long-standing question. Translocations within Igh involve DNA double-strand breaks… (More)
DOI: 10.1038/nature08633

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