Long noncoding RNAs in cardiac development and pathophysiology.

  title={Long noncoding RNAs in cardiac development and pathophysiology.},
  author={Nicole Schonrock and Richard P. Harvey and John S. Mattick},
  journal={Circulation research},
  volume={111 10},
Heart function requires sophisticated regulatory networks to orchestrate organ development, physiological responses, and environmental adaptation. Until recently, it was thought that these regulatory networks are composed solely of protein-mediated transcriptional control and signaling systems; consequently, it was thought that cardiac disease involves perturbation of these systems. However, it is becoming evident that RNA, long considered to function primarily as the platform for protein… CONTINUE READING
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