Long noncoding RNAs: fresh perspectives into the RNA world.

  title={Long noncoding RNAs: fresh perspectives into the RNA world.},
  author={Lin Yang and John E Froberg and Jeannie T Lee},
  journal={Trends in biochemical sciences},
  volume={39 1},
Large-scale mapping of transcriptomes has revealed significant levels of transcriptional activity within both unannotated and annotated regions of the genome. Interestingly, many of the novel transcripts demonstrate tissue-specific expression and some level of sequence conservation across species, but most have low protein-coding potential. Here, we describe progress in identifying and characterizing long noncoding RNAs (lncRNAs) and review how these transcripts interact with other biological… CONTINUE READING

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