Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.

  title={Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.},
  author={Sofia A Quinodoz and Mitchell Guttman},
  journal={Trends in cell biology},
  volume={24 11},
Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and, specifically, within the chromatin-associated fraction. Consistent with their localization, many lncRNAs have been implicated in the regulation of gene expression and in shaping 3D nuclear organization. In this review, we discuss the evidence that many nuclear-retained lncRNAs can interact with various… CONTINUE READING
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