Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.

@article{Wang2015LongNR,
  title={Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.},
  author={Yang Wang and Huiling Zhong and Xiaodan Xie and Crystal Y. Chen and Dan ” Huang and Ling Shen and Hui Zhang and Z Chen and Gucheng Zeng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 29},
  pages={E3883-92}
}
Molecular mechanisms for T-cell immune responses modulated by T cell-inhibitory molecules during tuberculosis (TB) infection remain unclear. Here, we show that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8(+) T cells and that blockade of CD244 signaling enhances production of IFN-γ and TNF-α. CD244 expression/signaling in TB correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1-72) or lncRNA-CD244] in the… CONTINUE READING

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Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

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