Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia.

@article{Lu2017LongNR,
  title={Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia.},
  author={Yinghao Lu and Yan Li and Xiao Chai and Qian Kang and Peng Zhao and Jie Xiong and Ji Shi Wang},
  journal={Gene},
  year={2017},
  volume={607},
  pages={41-46}
}
Aberrant expression of long noncoding RNA (lncRNA) HULC is associated with various human cancers. However, the role of HULC in chronic myeloid leukemia (CML) is unknown. In this study, we found that HULC was remarkably overexpressed in both leukemia cell lines and primary hematopoietic cells derived from CML patients. The increase in HULC expression was positively correlated with clinical stages in CML. Moreover, the knockdown of HULC significantly inhibited CML cell proliferation and induced… CONTINUE READING
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