Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression

@article{Hirano2015LongNR,
  title={Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression},
  author={T. Hirano and Ryoko Yoshikawa and H. Harada and Y. Harada and A. Ishida and T. Yamazaki},
  journal={Molecular Cancer},
  year={2015},
  volume={14}
}
BackgroundAccumulating evidence suggests that some long noncoding RNAs (lncRNAs) are involved in certain diseases, such as cancer. The lncRNA, CCDC26, is related to childhood acute myeloid leukemia (AML) because its copy number is altered in AML patients.ResultsWe found that CCDC26 transcripts were abundant in the nuclear fraction of K562 human myeloid leukemia cells. To examine the function of CCDC26, gene knockdown (KD) was performed using short hairpin RNAs (shRNAs), and four KD clones, in… Expand
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