Long non-coding RNAs in cancer progression

  title={Long non-coding RNAs in cancer progression},
  author={K. Tano and N. Akimitsu},
  journal={Frontiers in Genetics},
  • K. Tano, N. Akimitsu
  • Published 2012
  • Medicine, Biology
  • Frontiers in Genetics
  • Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant. In many cases, lncRNAs act as key molecules in the regulation of processes such as chromatin remodeling, transcription, and post-transcriptional processing. Several lncRNAs (e.g., MALAT1… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    On the classification of long non-coding RNAs
    • 473
    The role of long non-coding RNAs in genome formatting and expression
    • 86
    • PDF


    Publications referenced by this paper.
    Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • 3,746
    • Highly Influential
    • PDF
    Long non-coding RNAs: insights into functions
    • 3,775
    • PDF
    Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • 4,557
    • PDF
    Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
    • 3,376
    • PDF
    Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
    • 2,379
    • PDF
    Long noncoding RNAs: functional surprises from the RNA world.
    • 1,634
    • PDF
    CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
    • 750
    • PDF