Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) β: LncRNA-hit-mediated TGFβ-induced epithelial to mesenchymal transition in mammary epithelia.

@article{Richards2015LongNR,
  title={Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) β: LncRNA-hit-mediated TGFβ-induced epithelial to mesenchymal transition in mammary epithelia.},
  author={Edward J Richards and G U Zhang and Zhu-Peng Li and Jennifer Permuth-Wey and Sridevi Challa and Yajuan Li and William Kong and Su Dan and Marilyn M Bui and Domenico Coppola and Wei-min Mao and Thomas A. Sellers and Jin Quan Cheng},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 11},
  pages={6857-67}
}
Long noncoding RNAs (lncRNAs) are emerging as key regulators in various biological processes. Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by tumor cells to depart from the primary tumor site, invade surrounding tissue, and establish distant metastases. Transforming growth factor β (TGFβ) signaling has been shown to be a major inducer of EMT and to facilitate breast cancer metastasis. However, the role of lncRNAs in this process remains largely unknown. Here we… CONTINUE READING

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