Long non-coding RNAs: new players in cell differentiation and development

@article{Fatica2014LongNR,
  title={Long non-coding RNAs: new players in cell differentiation and development},
  author={Alessandro Fatica and Irene Bozzoni},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={7-21}
}
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels… 
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References

SHOWING 1-10 OF 137 REFERENCES
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
TLDR
This expanding inventory of small and long non-coding RNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.
Long Noncoding RNAs with Enhancer-like Function in Human Cells
Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy.
TLDR
The present review revise the current knowledge of how small non-coding RNAs and lncRNAs (long non-CodingRNAs) impinge on circuitries controlling proper muscle differentiation and homoeostasis and how their biogenesis is regulated and provides new insights into an additional mechanism of post-transcriptional regulation mediated by lncRNA 'sponges'.
Genome regulation by long noncoding RNAs.
The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. The discovery of extensive transcription of large RNA…
Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation.
TLDR
A novel layer of regulation of cell differentiation and apoptosis by a lncRNA is revealed, explaining in part the inhibition of programmed cell death in mouse erythroid cells.
Control of somatic tissue differentiation by the long non-coding RNA TINCR
TLDR
It is shown that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mechanism.
Extensive and coordinated transcription of noncoding RNAs within cell cycle promoters
TLDR
This work uses an ultrahigh-density array that tiles the promoters of 56 cell-cycle genes to interrogate 108 samples representing diverse perturbations and identifies 216 transcribed regions that encode putative lncRNAs, many with RT-PCR–validated periodic expression during the cell cycle.
Transposable elements reveal a stem cell-specific class of long noncoding RNAs
TLDR
TEs pervade lincRNAs, dividing them into classes, and may have shaped lincRNA evolution and function by conferring tissue-specific expression from extant transcriptional regulatory signals.
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Modular regulatory principles of large non-coding RNAs
TLDR
This work synthesizes studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.
...
1
2
3
4
5
...