Long non-coding RNAs: new players in cell differentiation and development

  title={Long non-coding RNAs: new players in cell differentiation and development},
  author={Alessandro Fatica and Irene Bozzoni},
  journal={Nature Reviews Genetics},
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels… 
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