Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis

@article{AchaSagredo2020LongNR,
  title={Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis},
  author={Amelia Acha-Sagredo and Bubaraye Uko and Paschalia Pantazi and Naiara G. Bediaga and Chryssanthi Moschandrea and Lucille Rainbow and Michael Williams Marcus and Michael P. A. Davies and John K. Field and Triantafillos Liloglou},
  journal={British Journal of Cancer},
  year={2020},
  volume={122},
  pages={1050 - 1058}
}
Background Long non-coding RNAs compose an important level of epigenetic regulation in normal physiology and disease. Despite the plethora of publications of lncRNAs in human cancer, the landscape is still unclear. Methods Microarray analysis in 44 NSCLC paired specimens was followed by qPCR-based validation in 29 (technical) and 38 (independent) tissue pairs. Cross-validation of the selected targets was achieved in 850 NSCLC tumours from TCGA datasets. Results Twelve targets were successfully… 
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41 Citations
Background Citations
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Methods Citations
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Results Citations
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41 Citations

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Taken together, LINC01929 functioned as a tumor-promoting lncRNA via the miR-137-3p/FOXC1 axis in OSCC, suggesting novel targets for OSCC therapy.
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TLDR
It is suggested that NUTM2A-AS1 knockdown may inhibit LUAD progression by regulating the miR-590-5p/METTL3 axis and may provide insight into the mechanisms underlying the tumorigenesis of LUAD and offer a new treatment strategy for the disease.
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TLDR
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TLDR
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Exosomal Long Non-Coding RNAs in Lung Diseases
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The need for additional studies describing the lncRNA mechanisms of action and confirming their potential as biomarkers, as well as their involvement in resistance to treatment, especially in non-cancerous lung diseases is concluded.
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