Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer.

@article{Li2018LongNR,
  title={Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer.},
  author={Chang Li and Liang Rong Wan and Zeyi Liu and Guangquan Xu and Shengjie Wang and Zhiyue Su and Yingxi Zhang and Cuijuan Zhang and Xia Liu and Zhe Lei and Hong-tao Zhang},
  journal={Cancer letters},
  year={2018},
  volume={418},
  pages={185-195}
}
Growing evidence shows that lncRNA XIST functions as an oncogene accelerating tumor progression. Transforming growth factor β (TGF-β)-induced epithelial-mesenchymal transition (EMT) plays a key role in tumor metastasis. However, it is still unclear whether lncRNA XIST is implicated in TGF-β-induced EMT and influences cell invasion and metastasis in non-small-cell lung cancer (NSCLC). Here, we observed increased expression of lncRNA XIST and ZEB2 mRNA in metastatic NSCLC tissues. Knockdown of… CONTINUE READING
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