Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation

@article{Ding2019LongNR,
  title={Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation},
  author={Hongda Ding and Junpeng Liu and Ruoyao Zou and P.-T. Cheng and Yang Su},
  journal={Journal of Experimental \& Clinical Cancer Research : CR},
  year={2019},
  volume={38}
}
  • Hongda Ding, Junpeng Liu, Yang Su
  • Published 9 May 2019
  • Biology, Medicine, Chemistry
  • Journal of Experimental & Clinical Cancer Research : CR
BackgroundHepatocellular carcinoma (HCC) is still the most common cause of tumor-related death worldwide and accumulating studies report that long non-coding RNAs (LncRNAs) are closely related with HCC development, metastasis and prognosis. Cisplatinum, a well-known chemotherapeutic drug, has been widely used for treatment of numerous human cancers including HCC. This study aimed to investigate the differential expressions of LncRNAs in HCC cells treated with cisplatinum and its underlying… 
Long non-coding RNA TPTEP1 exerts inhibitory effects on hepatocellular carcinoma by impairing microRNA-454-3p-mediated DLG5 downregulation.
Silencing LncRNA SCAMP1 Inhibits Cell Proliferation in Hepatocellular Carcinoma via Activation of p53 Signaling Pathway
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The study showed that TPTEP1 played an inhibitory role in cancer progression of NSCLC cells by regulating miR-761/LATS2 cascade, thereby highlighting the potential therapeutic significance of T PTEP1/miR- 761/ LATS2 axis.
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TLDR
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TLDR
The findings unmasked a feedback loop of TPTEP1/JNK/c-JUN/miR-1303 axis in AML cells, suggesting T PTEP1 and miR- 1303 as potential targets for developing therapeutic strategies for AML patients.
lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells
TLDR
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The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma
TLDR
The recent finding about the impact of lncRNAs in HCC is described, which indicates that a number of so-called tumor suppressor lnc RNAs namely CASS2 and MEG3 are down-regulated in H CC.
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