Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152

@article{Zheng2016LongNR,
  title={Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152},
  author={Jianjian Zheng and Fujun Yu and Peihong Dong and Limei Wu and Yuan Zhang and Yan-Wei Hu and Lei Zheng},
  journal={Oncotarget},
  year={2016},
  volume={7},
  pages={62886 - 62897}
}
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was… 
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  • Tao HuangHong Wei Liu Bin Wang
  • Biology
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  • 2017

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