Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152

@article{Zheng2016LongNR,
  title={Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152},
  author={Jianjian Zheng and Fu-jun Yu and Peihong Dong and Limei Wu and Yuan Zhang and Yan-Wei Hu and Lei Zheng},
  journal={Oncotarget},
  year={2016},
  volume={7},
  pages={62886 - 62897}
}
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was… 
Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer.
TLDR
It is reported that PVT1 promotes prostate cancer invasion and metastasis by modulating EMT and can promote EMT by up-regulation of Twist1, a transcription factor associated with EMT, and the PVT 1/miR-186/Twist1 regulatory axis may be a new therapeutic target for prostate cancer.
MicroRNA-30a Suppresses the Activation of Hepatic Stellate Cells by Inhibiting Epithelial-to-Mesenchymal Transition
TLDR
The results suggest that miR-30a inhibits EMT process, at least in part, via reduction of Snai1, leading to the suppression of HSC activation in liver fibrosis.
The long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer.
  • Tao Huang, Hong Wei Liu, +4 authors Bin Wang
  • Biology, Medicine
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2017
TLDR
PVT1 expression was markedly upregulated in GC tissues and cell lines, and high expression levels of PVT1 were obviously correlated with advanced tumor stage and lymph node metastasis, suggesting that PVT 1 acted as a key role in GC pathogenesis and may serve as a potential therapeutic target for GC.
Regulatory long non-coding RNAs of hepatic stellate cells in liver fibrosis (Review)
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The present review highlighted the current knowledge on the role of lncRNAs in activating or inhibiting LF, revealing lnc RNAs that are likely to be biomarkers or therapeutic targets for LF.
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The findings support a model in which the PVT1-214/Lin28/let-7 axis serves as a critical regulator of CRC pathogenesis, which may simulate a new direction for CRC therapeutic development.
H19/miR‐148a/USP4 axis facilitates liver fibrosis by enhancing TGF‐β signaling in both hepatic stellate cells and hepatocytes
TLDR
A novel H19/miR‐148a/USP4 axis which promoted liver fibrosis via TGF‐β pathway in both HSC and hepatocyte is revealed, indicating that H19 could become a promising target for the treatment of liver fibrogenesis.
A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation.
TLDR
A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis that modulates HSC activation and might exert an effect on the pathogenesis of liver fibrosis is demonstrated.
Long non‐coding RNA PVT1: Emerging biomarker in digestive system cancer
TLDR
PVT1 promotes proliferation, survival, invasion, metastasis and drug resistance in digestive system cancer cells, and there was a great probability it could be a novel biomarker in screening tumours, prognosis biomarkers and future targeted therapy to improve the survival rate in cancer patients.
Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1
TLDR
It is shown that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts and the first evidence of dysregulated PVT 1/miR-203/LASP1 axis in ES CC is provided.
The Roles and Mechanisms of lncRNAs in Liver Fibrosis
TLDR
A review of the functions and mechanisms of lncRNAs, the lncRNA transcriptome profile of liver fibrosis, and the main lnc RNAs involved in the signalling pathways that regulate hepatic fibrosis provides insight into the screening of therapeutic and diagnostic markers of Liver fibrosis.
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