Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b.

@article{Tsang2015LongNR,
  title={Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b.},
  author={Felice Ho-Ching Tsang and Sandy Leung-Kuen Au and Lai Wei and Dorothy Ngo-yin Fan and Joyce M. Lee and Carmen Chak-lui Wong and Irene Oi-lin Ng and Chun-Ming Wong},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2015},
  volume={35 5},
  pages={1597-606}
}
BACKGROUND & AIMS Hepatocellular carcinoma (HCC) is one of the most common human cancers. Recently, emerging evidence has suggested the role of long non-coding RNAs (lncRNAs) in human carcinogenesis. In this study, we aimed to investigate the expression and functional implications of lncRNAs in human HCC. METHODS Eighty-eight well-annotated lncRNAs were profiled in primary HCC by quantitative RT-PCR. Functional relevance of lncRNAs was elucidated in HCC cell lines and nude mice models. The… CONTINUE READING
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