Long non-coding RNA CRNDE promotes heptaocellular carcinoma cell proliferation by regulating PI3K/Akt /β-catenin signaling.

@article{Tang2018LongNR,
  title={Long non-coding RNA CRNDE promotes heptaocellular carcinoma cell proliferation by regulating PI3K/Akt /β-catenin signaling.},
  author={Qiling Tang and Xiaoli Zheng and Junkai Zhang},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2018},
  volume={103},
  pages={
          1187-1193
        }
}
Hepatocellular carcinoma (HCC) is one of the common malignant cancer worldwide, and its molecular pathogenesis remains elusive and recently long non-coding RNAs (lncRNAs) have been reported that play divergent roles in HCC tumorigenesis and development. In current study, we found a lncRNA, CRNDE is more commonly up-regulated in HCC malignant tissues and associated with poor clinical outcomes. Furthermore, both loss- and gain-functions assays revealed that CRNDE promotes HCC cell proliferation… CONTINUE READING

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