Long-lived rodents reveal signatures of positive selection in genes associated with lifespan

@article{Sahm2018LonglivedRR,
  title={Long-lived rodents reveal signatures of positive selection in genes associated with lifespan},
  author={A. Sahm and M. Bens and K. Szafranski and S. Holtze and M. Groth and M. G{\"o}rlach and C. Calkhoven and C. M{\"u}ller and M. Schwab and J. Kraus and H. Kestler and A. Cellerino and H. Burda and T. Hildebrandt and P. Dammann and M. Platzer},
  journal={PLoS Genetics},
  year={2018},
  volume={14}
}
The genetics of lifespan determination is poorly understood. Most research has been done on short-lived animals and it is unclear if these insights can be transferred to long-lived mammals like humans. Some African mole-rats (Bathyergidae) have life expectancies that are multiple times higher than similar sized and phylogenetically closely related rodents. To gain new insights into genetic mechanisms determining mammalian lifespans, we obtained genomic and transcriptomic data from 17 rodent… Expand
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