Long-lived reactive species on free-radical-damaged proteins.

  title={Long-lived reactive species on free-radical-damaged proteins.},
  author={Jacob S. Simpson and Shin-ichiro Narita and Steven P Gieseg and Silvia Gebicki and Janusz M Gebicki and Roger T. Dean},
  journal={The Biochemical journal},
  volume={282 ( Pt 3)},
We have demonstrated two novel reactive species on radical-modified proteins which are relatively long-lived, one oxidizing and one reducing. The two species are reactive with critical biological components, and so may be of physiological and pathological importance. The oxidizing species, which have been identified as protein hydroperoxides, can consume key cellular reductants, such as ascorbate and glutathione. The reducing species can act on both free and metalloprotein forms of copper and… CONTINUE READING
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