Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses.

Abstract

Cellular proliferation depends on the integration of mitogenic stimuli with environmental conditions. Increasing evidence suggests that microRNAs play a regulatory role in this integration. Here we show that during periods of cellular quiescence, mature microRNAs are stabilized and stored in Argonaute protein complexes that can be activated by mitogenic… (More)
DOI: 10.1073/pnas.1219958110

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@article{Olejniczak2013LonglivedMC, title={Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses.}, author={Scott H Olejniczak and Gaspare La Rocca and Joshua J. Gruber and Craig B Thompson}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2013}, volume={110 1}, pages={157-62} }