Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat

  title={Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat},
  author={R. Seigers and S. Schagen and W. Beerling and W. Boogerd and B. Buwalda},
  journal={Behavioural Brain Research},
  • R. Seigers, S. Schagen, +2 authors B. Buwalda
  • Published 2008
  • Psychology, Medicine
  • Behavioural Brain Research
  • Methotrexate (MTX) is a cytostatic agent widely used in combination with other agents as adjuvant chemotherapy for breast cancer and is associated with cognitive impairment as a long-term side effect in some cancer patients. This paper aimed to identify a neurobiological mechanism possibly responsible for this cognitive impairment using an animal model. The first study explored the hypothesis that MTX reduces neuronal cell proliferation. A dose-dependent long-lasting decrease in hippocampal… CONTINUE READING
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