Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice

@article{Tsunematsu2013LonglastingSO,
  title={Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice},
  author={Tomomi Tsunematsu and Sawako Tabuchi and Kenji F Tanaka and Edward S. Boyden and Makoto Tominaga and Akihiro Yamanaka},
  journal={Behavioural Brain Research},
  year={2013},
  volume={255},
  pages={64-74}
}
Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. Recent optogenetic studies revealed that the activation or inhibition of orexin neuronal activity affects the probability of sleep/wakefulness transition in the acute phase. To expand our understanding of how orexin neurons maintain wakefulness, we generated new transgenic mice in which orexin neurons expressed archaerhodopsin from Halorubrum strain TP009 (ArchT), a green light-driven neuronal silencer… CONTINUE READING
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