Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids.

Hippocampal CA1 pyramidal neurons receive sensory inputs from the entorhinal cortex directly through the perforant path (PP) and indirectly through Schaffer collaterals (SC). Direct cortical inputs to CA1 pyramidal neurons through the PP provide instructive signals for hippocampal long-term synaptic plasticity. However, the molecules conveying synaptic… (More)