Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures.

@article{Notenboom2010LonglastingMO,
  title={Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures.},
  author={Robbert G E Notenboom and Geert M. J. Ramakers and Amer Kamal and Berry M. Spruijt and Pierre N. E. de Graan},
  journal={The European journal of neuroscience},
  year={2010},
  volume={32 5},
  pages={749-58}
}
A small fraction of children with febrile seizures appears to develop cognitive impairments. Recent studies in a rat model of hyperthermia-induced febrile seizures indicate that prolonged febrile seizures early in life have long-lasting effects on the hippocampus and induce cognitive deficits. However, data on network plasticity and the nature of cognitive deficits are conflicting. We examined three specific measures of hippocampal plasticity in adult rats with a prior history of experimental… CONTINUE READING