Long-lasting kidney graft survival after immunization with antibody-coated blood cells: mediation by immunosuppressive autoantibodies.

@article{Terness1990LonglastingKG,
  title={Long-lasting kidney graft survival after immunization with antibody-coated blood cells: mediation by immunosuppressive autoantibodies.},
  author={Peter I Terness and R Schiffl and Caner S{\"u}sal and Zhen George Guo and Gerhard Opelz},
  journal={Immunology letters},
  year={1990},
  volume={26 2},
  pages={139-44}
}
Treatment of LEW rats before transplantation with BN blood cells preincubated with LEW-anti-BN serum resulted in prolonged BN kidney graft survival (untreated, 8 +/- 0.4 days; pretreated, 124 +/- 36). The serum of pretreated animals contains a factor which suppresses T cell proliferation against donor antigens. This effect was not mediated by antiidiotypic antibodies because it was reproduced in a donor-unrelated system. The serum and IgG of pretreated animals also suppressed the humoral immune… CONTINUE READING