Long-lasting facilitation of excitatory postsynaptic potentials in the rat hippocampus by acetylcholine.

  title={Long-lasting facilitation of excitatory postsynaptic potentials in the rat hippocampus by acetylcholine.},
  author={Henry Markram and Menahem Segal},
  journal={The Journal of physiology},
1. The effects of acetylcholine (ACh) on excitatory postsynaptic potentials (EPSPs) evoked by stimulating Schaffer-commissural afferents and on ionophoretically applied L-glutamate ligands, were investigated in CA1 neurones of hippocampal slices using current- and voltage-clamp techniques. 2. ACh produced a transient suppression followed by a long-lasting facilitation of EPSPs. The facilitation was also seen in Cs(+)-filled cells under voltage-clamp conditions. Both suppressing and facilitating… CONTINUE READING
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