Long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine.

@article{Girod2001LonglastingEO,
  title={Long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine.},
  author={Romain Girod and Lorna W Role},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 14},
  pages={5182-90}
}
Attempts to mimic synaptic delivery of acetylcholine (ACh) with brief, repetitive pulses of high concentration ACh at synapses of medial habenula (MHN) and interpeduncular nucleus (IPN) neurons in vitro elicited temporally distinct facilitation and inhibition of glutamate secretion via nicotinic and muscarinic ACh receptor-mediated pathways, respectively. ACh-induced nicotinic facilitation was sustained for up to 2 hr, whereas muscarinic inhibition was transient. Prolonged exposure to nicotine… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 65 references

Cholinergic systems in mammalian brain and spinal cord

Progress in Neurobiology • 1991
View 4 Excerpts
Highly Influenced

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