Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation

@article{OConnor1994LonglastingEO,
  title={Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation},
  author={John J. O'Connor and Michael J. Rowan and Roger Anwyl},
  journal={Nature},
  year={1994},
  volume={367},
  pages={557-559}
}
SYNAPTIC transmission mediated by the N-methyl-D-aspartate (NMDA) glutamate receptor plays a key role in a range of plastic processes in the nervous system. These include long-term potentiation of synaptic transmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor, neuronal development, excitotoxicity and certain learning tasks1,2. Recently, long-term potentiation of NMDA receptor-mediated synaptic transmission was found to occur following high-frequency… CONTINUE READING
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