Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits.

@article{Walker2007LonglastingEO,
  title={Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits.},
  author={Claire-Dominique Walker and Hong Long and Sylvain Williams and Denis Richard},
  journal={Journal of neuroscience research},
  year={2007},
  volume={85 4},
  pages={
          816-28
        }
}
The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-term consequences on long-term potentiation (LTP) in adulthood. We first showed that in postnatal day (PND) 10 neonates, acute leptin treatment functionally activated leptin… CONTINUE READING
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