Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.

@article{Facchinetti1994LonglastingEO,
  title={Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.},
  author={Fabrizio Facchinetti and Rossella Dall'olio and Elisabetta Ciani and Mauro Sparapani and Marco Virgili and Antonio Contestabile},
  journal={Neuroscience},
  year={1994},
  volume={60 2},
  pages={343-53}
}
A competitive antagonist of the N-methyl-D-aspartate receptor, CGP 39551, was administered daily to neonatal rats with increasing doses from postnatal day 1 to 22. These animals displayed approximately 50% decrease of body weight at the end of treatment and, therefore, both normal and neonatally undernourished rats were used as controls. At a young adult stage (55-75 days of age) CGP 39551-treated rats showed a much higher spontaneous locomotor activity as compared to control groups. This… CONTINUE READING