Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.

@article{Kleinnijenhuis2014LonglastingEO,
  title={Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.},
  author={Johanneke Kleinnijenhuis and Jessica Quintin and Frank W. M. B. Preijers and Christine Stabell Benn and Leo A B Joosten and C. Jacobs and Joke van Loenhout and Ramnik J. Xavier and Peter Aaby and Jos W M van der Meer and Reinout van Crevel and Mihai G Netea},
  journal={Journal of innate immunity},
  year={2014},
  volume={6 2},
  pages={152-8}
}
We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination… CONTINUE READING

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Potential health effects from non-specific stimulation of the immune function in early age: the example of BCG vaccination.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology • 2008

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