Long lasting consequences of cannabis exposure in adolescence

@article{Rubino2008LongLC,
  title={Long lasting consequences of cannabis exposure in adolescence},
  author={Tiziana Rubino and Daniela Parolaro},
  journal={Molecular and Cellular Endocrinology},
  year={2008},
  volume={286},
  pages={S108-S113}
}
  • T. Rubino, D. Parolaro
  • Published 16 April 2008
  • Psychology, Biology
  • Molecular and Cellular Endocrinology

Tables from this paper

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory
Chronic exposure to cannabinoids during adolescence causes long‐lasting behavioral deficits in adult mice
TLDR
It is demonstrated that long‐term administration of 3 mg/kg of WIN during adolescence leads to increased endocannabinoid levels and altered Rgs7 expression in adulthood and establish a potential link to epigenetic changes.
Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood
TLDR
Surprisingly, in comparison to clean air controls rats exposed to either cannabis or placebo smoke in adolescence exhibited enhanced performance on a delayed response working memory task, consistent with a growing body of evidence for limited long-term adverse cognitive and affective consequences of adolescent exposure to relatively low levels of cannabinoids.
Endocannabinoids in brain plasticity: Cortical maturation, HPA axis function and behavior
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 66 REFERENCES
Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates
TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.
Short-term memory impairment in cannabis-dependent adolescents.
TLDR
It is concluded that cannabis-dependent adolescents have selective short-term memory deficits that continue for at least 6 weeks after the last use of marijuana.
Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats
TLDR
It is concluded that chronic cannabinoid exposure leads to long-term memory impairments and increased anxiety, irrespective of the age at which drug exposure occurrs.
Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats
TLDR
It is suggested that chronic exposure to a cannabinoid receptor agonist well after the immediate postnatal period, but before reaching sexual maturity, can lead to increased anxiety and a lasting impairment of working memory.
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
TLDR
This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26.
Cannabinoids and gene expression during brain development
TLDR
All evidence relating cannabinoids to the expression of key genes for neural development is reviewed, trying to establish the future research addressed to elucidate the mechanisms involved in the epigenetic action of cannabinoids during brain development.
Cannabis use and psychosocial adjustment in adolescence and young adulthood.
TLDR
Cannabis use, and particularly regular or heavy use, was associated with increased rates of a range of adjustment problems in adolescence/ young adulthood-other illicit drug use, crime, depression and suicidal behaviours-with these adverse effects being most evident for school-aged regular users.
The adolescent brain and age-related behavioral manifestations
  • L. Spear
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2000
...
1
2
3
4
5
...