Long-lasting antinociceptive effect of RC-160, a somatostatin analog, in mice and rats.

@article{Eschalier1991LonglastingAE,
  title={Long-lasting antinociceptive effect of RC-160, a somatostatin analog, in mice and rats.},
  author={Alain Eschalier and Olivier Auma{\^i}tre and Denis Ardid and Joseph Fialip and Pierre Duch{\^e}ne-Marullaz},
  journal={European journal of pharmacology},
  year={1991},
  volume={199 1},
  pages={119-21}
}
The effect of RC-160 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2) was studied in mice by means of the hot plate test and in rats with the tail flick test. In mice, 512 micrograms/kg (s.c.) induced an antinociceptive effect maximal (+88 +/- 17%) at the 6th hour after injection but still significant at the 24th hour; 16 micrograms/kg (s.c.) was active for 3 h; 64, 256 and 1024 micrograms/kg were active 30 min, 3 and 24 h after injection. The effects of these last three doses were not different. The… CONTINUE READING

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