Long-lasting alterations of the mesolimbic dopamine system after periadolescent ethanol drinking by alcohol-preferring rats.

@article{Sahr2004LonglastingAO,
  title={Long-lasting alterations of the mesolimbic dopamine system after periadolescent ethanol drinking by alcohol-preferring rats.},
  author={Allison E Sahr and Richard J Thielen and Lawrence Lumeng and T. K. Li and William J H Mcbride},
  journal={Alcoholism, clinical and experimental research},
  year={2004},
  volume={28 5},
  pages={702-11}
}
BACKGROUND This study tested the hypothesis that ethanol consumption by alcohol-preferring (P) rats during the periadolescent period causes persistent alterations in the mesolimbic dopamine (DA) system. After ethanol drinking during periadolescence, P rats were examined for alterations in basal locomotor activity, changes in extracellular DA levels and extraction fraction in the nucleus accumbens (NAc) by using no-net-flux (NNF) microdialysis, and changes in the response of the mesolimbic DA… CONTINUE READING