Long intergenic noncoding RNAs: new links in cancer progression.

  title={Long intergenic noncoding RNAs: new links in cancer progression.},
  author={Miao-Chih Tsai and Robert C. Spitale and Howard Y Chang},
  journal={Cancer research},
  volume={71 1},
The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs… CONTINUE READING

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