Long-distance cue from emerging dermis stimulates neural crest melanoblast migration.

@article{Tosney2004LongdistanceCF,
  title={Long-distance cue from emerging dermis stimulates neural crest melanoblast migration.},
  author={Kathryn W. Tosney},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={229 1},
  pages={99-108}
}
  • Kathryn W. Tosney
  • Published 2004 in
    Developmental dynamics : an official publication…
Neural crest melanoblasts display unique navigational abilities enabling them to colonize the dorsal path between ectoderm and somite. One signal shown here to elicit melanoblast migration is a chemotactic cue supplied by the emerging dermis. Until dermis emerges, melanoblasts fail to enter the dorsal path. The dermis emerges from a site that is too distant to stimulate migration by cell contact. Instead, surgeries show that dermis elicits migration from a distance. When dermis is grafted… CONTINUE READING